How can I disable structure padding in C without using pragma?
Other than compiler options like pragma pack, you cannot, padding is in the C Standard.
You can always attempt to reduce padding by declaring the smallest types last in the structure as in:
struct _foo {
int a; /* No padding between a & b */
short b;
} foo;
struct _bar {
short b; /* 2 bytes of padding between a & b */
int a;
} bar;
Note for implementations which have 4 byte boundaries