I have a VS solution containing several projects. While debugging a particular project all the source files are locked by VS. I would like to unlock sources that the debugee
The Edit and Continue feature is preventing you from editing files if the debugger hasn't stopped the program. The simple workaround is Debug + Break All, you should then be able to edit the files, your changes will be immediately effective provided your changes do not violate the restrictions imposed by E+C. This is the most efficient work flow.
The heavy-handed approach is to disable Edit and Continue. Tools + Options, Debugger, Edit and Continue, uncheck the Enable check box.