I have installed Win10, Visual Studio 2015, Python 2.7, Python 3.5 and PTVS 2.2.3.
Unfortunately PTVS does not work at all. I can not load any Python projects that w
You'll need to open the ActivityLog.xml (%APPDATA%\Microsoft\VisualStudio\14.0\ActivityLog.xml) and see if there's any exceptions there related to PTVS.
It sounds like you have a pretty messed up configuration at this point. You could try uninstalling PTVS and re-installing it, but my guess is your messed up Python installs are somehow throwing PTVS off and causing it to crash somewhere.