(I asked this question in another way, and got some interesting responses but I\'m not too convinced.)
Is Mono\'s GtkSharp truly cross-platform? It seems to be Gnome
Gtk# is cross platform. However the only platform where it looks nice is Linux/BSD running GNOME. If possible somehow, separate frontend and backend and develop separate user interfaces for Linux, Windows and OS X. Even wx, which does a really good job in looking okay on all three platforms, has its limits.
Working Mac/PC/Linux app in Gtk#? Tomboy runs on all three I think.