I just start a simple project called flask_wiki this days and I\'m using some flask extensions as the follows:
According to what I've read in the docs, you can specify a model_converter attribute in your ModelSchema Meta class. The ModelConverter class has a SQLA_TYPE_MAPPING attribute you can override in a subclass to add your custom GUID field to the types detected by the automatic schema generator.
That said, I've never used it so I don't know if this will work or not.