create/append node vs innerHTML

Question

Does anyone have a good reason to use one over the other? As far as I can tell, create/append node simply prevents you from creating invalid code, while innerHTML allows you

Answer 1

If performance matters, it's good to know that the innerHTML is relatively fast, especially in MSIE: http://www.quirksmode.org/dom/innerhtml.html

It has however the bad image of originally being a "Microsoft proprietary" property and/or not really "OO".