I\'m fairly well versed in SQL server performace but I constanly have to argue down the idea that GUIDs should be used as the default type for Clusterd Primary Keys.
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Using a guid (unless it is a sequential GUID) as a clustered index is going to kill insert performance. Since the physical table layout is aligned according to the clustered index, using a guid which has a random sequencing order will cause serious table fragmentation. If you want to use a guid as a PK/Clustered index it must be a sequential guid using the newsequentialid() function in sql server. This will guarantee that the generated guids are ordered sequentially and prevent fragmentation.