Say I want to write a comparison sorting function, I can hint that the input must be a sequence with Sequence[T] (or MutableSequence[T] in this cas
As noted in the comments, Comparable isn't a state of being, it's only meaningful as a descriptor for a pair of types. Usually, a sorting function is working with homogeneous types though, so as long as you don't mind the type checker only handling the concept of "supports < with some types" rather than "supports < with arbitrary types", you can define your own Comparable and bound a typing TypeVar with it. Conveniently, PEP484 (which defines typing hints) already provides an example of how you'd do this:
from abc import ABCMeta
from typing import Any, TypeVar
class Comparable(metaclass=ABCMeta):
@abstractmethod
def __lt__(self, other: Any) -> bool: ...
CT = TypeVar('CT', bound=Comparable)
You can then use this for your comparable_sort definition with:
def comparable_sort(s: MutableSequence[CT]) -> None:
Note that I only required __lt__ to be defined; as a rule, Python 3 implements its own sorting functions entirely in terms of __lt__ (it doesn't use any of the other rich comparator operators, not even __eq__)†, so it's a good idea to design your own algorithm the same way, so anything sorted can handle, you can handle the same way.
†: Python 2 originally used __le__ in at least one place (heapq), but it's been intentionally, consistently, __lt__ for the builtins and standard library in the Python 3 timeframe, and your style of typing is Python 3-only anyway.