I\'m a newbie in the Python and GAE world and I have a question. With Python the normal approach is to only optimize the code when needed, fixing the more urgent bottlenecks
See Can I write parts of the Google App Engine code in Java, other parts in Python? for how to use multiple languages.
Basically, each version of a given app can only use one runtime language.
But, you can have two different versions of your app, written in different languages, and they can pass information back and forth through the datastore.
Also, you can have two different apps, in two different languages, and you can have then pass information back and forth through requests.