I want to do a simple lambda expression like this:
IList list = GetSomeList();
MyEntity1 result = list.SingleOrDefault(
If you want to use the "query comprehension" syntactic form you can do this:
var query = from entity1 in list
let entity2 = GetMyEntity2(entity1)
where entity2 != null
where entity2.Id != null
where entity2.Id > 0
select entity1;
var result = query.SingleOrDefault();
Note also that the middle "where" clause might not be necessary. If "entity2.Id" is a nullable int then it will be correctly checked for null by the lifted > operator.