If I\'ve got this:
In a word: no.
Given the current structure of your HTML (and the current state of CSS selectors), this is not possible. Perhaps we will get something like this in CSS4, but traversal like this is best left up to Javascript.
You can obviously restructure your markup, and use the sibling selector:
HTML
Trigger
Hello
CSS
#trigger:hover + .sibling #change {
color:red;
}
codepen