I am trying to edit a word document from VB.NET using for the most part this code:
How to automate Word from Visual Basic .NET to create a new document
I had the same issue on Windows 2008 R2. Ended up using this post: http://social.msdn.microsoft.com/Forums/en-US/netfx64bit/thread/65a355ce-49c1-47f1-8c12-d9cf5f23c53e
and then changing the impersonation identity user in web.config to another user to solve it.
I'm sure there is a combination of solutions.