I\'m trying to get rid of all DateTime.Now method calls and replace them with my own GetNow() method, which may sometimes return a fixed date for t
You could use Moles in your tests to provide your own DateTime.Now when required, without the need to modify any existing code that calls it.
Another option might be to modify the assembly after compilation to call something else. (Perhaps, use Mono.Cecil to rewrite the IL, and add a command to the post-build in VS to run it.)
You could perhaps grab the Mono source and build yourself a custom mscorlib with the function removed.