I set up a simple DataFrame in pandas:
a = pandas.DataFrame([[1,2,3], [4,5,6], [7,8,9]], columns=[\'a\',\'b\',\'c\'])
>>> print a
a b c
0 1 2
Alright I've found a way to solve this problem without chaining, and without worrying about multiple indices.
a.iloc[-1, a.columns.get_loc('a')] = 77
>>> a
a b c
0 1 2 3
1 4 5 6
2 77 8 9
I wasn't able to use iloc before because I couldn't supply the column index as an int, but get_loc solves that problem. Thanks for the helpful comments everyone!