So I got prompted to download the latest NuGet Package Manager in VS2010.
All previous updates (including this) has failed with:
VSIXInstaller.SignatureMismatchExc
If you want to delete/uninstall Nuget package which is applied to multiple projects in your solutions then go to:
Tools-> Nuget Package Manager -> Manage Nuget Packages for Solution
In the left column where is 'Installed packages' select 'All', so you'll see a list of installed packages and Manage button across them.
Select Manage button and you'll get a pop out, deselect the checkbox across project name and Ok it
The rest of the work Package Manager will do it for you.