In my table table1 there are 6 columns Locations,a,b,c,d,e.
Locations [a] [b] [c] [d] [e]
[1] 10.00 Null Null 20.00 Null
[2]
SQL is more about working on rows rather than columns.
If you're talking about deleting rows where c is null, use:
delete from table1 where c is null
If you're talking about dropping a column when all rows have null for that column, I would just find a time where you could lock out the DB from users and execute one of:
select c from table1 group by c
select distinct c from table1
select count(c) from table1 where c is not null
Then, if you only get back just NULL (or 0 for that last one), weave your magic (the SQL Server command may be different):
alter table table1 drop column c
Do this for whatever columns you want.
You really need to be careful if you're deleting columns. Even though they may be full of nulls, there may be SQL queries out there that use that column. Dropping the column will break those queries.