I had previously installed the VS11 beta, and had some issues with my Visual Studio 2010 instance, which you can see here how they were resolved: Excel AddIn Click Once depl
I had the same problem in Excel.
The following worked for me:
Go to the following key....
HKEY_CURRENT_USER\Software\Microsoft\Office\15.0\Excel\AddInLoadTimes
see if your plug-in is listed. if so, delete it.
now run your app from Visual studio again.
This worked for me, hope it can help someone else.