I had previously installed the VS11 beta, and had some issues with my Visual Studio 2010 instance, which you can see here how they were resolved: Excel AddIn Click Once depl
I had the same problem with a Word VSTO, but there was no Resiliency\DisabledItems folder in my registry, so I think it was never hard disabled (as in @mservidio's solution). What worked for me was to edit the Manifest path in HKEY_USERS\ to reflect the 'Debug' path rather than the 'Release' path.
To find the right folder it might be easiest just searching for the Add-In name and checking that any Manifest keys refer to the Debug path.
