I have a multi-project solution that I was building in Visual Studio 2013 and it was working fine but now that I have upgraded to Visual Studio 2015 I can no longer hit brea
I just fixed this issue for one of our front end developers. It may or may not apply to you. We use IIS Express for local debugging, and somehow his had become detached from the correct process when debugging.
To fix, I checked what process ID it was attached to according to IIS Express (right click IIS icon on taskbar, select Show All Applications, check the PID listed for the application). I then attached it to the proper process (with the solution running in VS, click Debug on the toolbar, select attach to process, find the correct process using the PID gotten above from IIS Express). Hope this helps someone.