Up until now i\'ve been using the C# \"Guid = Guid.NewGuid();\" method to generate a unique ID that can be stored as the ID field in some of my SQL Server database tables us
Both have pros and cons, it depends entirely on how you use them that matters.
Right off the bat, if you need identifiers that can work across several databases, you need GUIDs. There are some tricks with Long (manually assigning each database a different seed/increment), but these don't scale well.
As far as indexing goes, Long will give much better insert performance if the index is clustered (by default primary keys are clustered, but this can be modified for your table), since the table does not need to be reorganized after every insert.
As far as concurrent inserts are concerned however, Long (identity) columns will be slower then GUID - identity column generation requires a series of exclusive locks to ensure that only one row gets the next sequential number. In an environment with many users inserting many rows all the time, this can be a performance hit. GUID generation in this situation is faster.
Storage wise, a GUID takes up twice the space of a Long (8 bytes vs 16). However it depends on the overall size of your row if 8 bytes is going to make a noticable difference in how many records fit in one leaf, and thus the number of leaves pulled from disk during an average request.