I\'m currently building a project and I would like to make use of some simple javascript - I know some people have it disabled to prevent XSS and other things. Should I...>
"Degrade gracefully" is generally the best answer. But lots of sites now depend on JS - especially AJAX.
Consider your audience. If your site is aimed at extremely tech-savvy people, the chances of them not having javascript are small, and you can notify them to turn it on if necessary.
If your audience may access your site with mobile devices, don't assume they have JavaScript, and don't even assume they support CSS properly. Aim to degrade gracefully all the way down to bare HTML.