I develop application in C# with MSVC 2010 Express, with Forms/WPF/etc.
Application consist of some private assemblies (maybe DLLs) and .exe file. It uses .NET 4 fea
You didn't say what type of clients they are (are you making a small app for your friends to use or are they paying customers), but whatever the case may be, I'm always completely against sending a zip file with an instruction document describing what to do with it and what folder to extract it to. As Remy said, ClickOnce is not a bad idea, but I've found it to be a bit of a pain to set up (once you get it set up, though, it works just fine). On the other hand, a Deployment project is simpler and if I were you, that would be the first thing I'd explore.