I would like to take the original URL, truncate the query string parameters, and return a cleaned up version of the URL. I would like it to occur across the whole applicatio
I'm guessing that you want to do this because you want your users to see pretty looking URLs. The only way to get the client to "change" the URL in its address bar is to send it to a new location - i.e. you need to redirect them.
Are the query string parameters going to affect the output of your page? If so, you'll have to look at how to maintain state between requests (session variables, cookies, etc.) because your query string parameters will be lost as soon as you redirect to a page without them.
There are a few ways you can do this globally (in order of preference):
global.asax as you suggestYou should only use the 301 response code if the resource has indeed moved permanently. Again, this depends on whether your application needs to use the query string parameters. If you use a permanent redirect a browser (that respects the 301 response code) will skip loading a URL like .../default.aspx?utm_source=twitter&utm_medium=social-media and load .../default.aspx - you'll never even know about the query string parameters.
Finally, you can use POST method requests. This gives you clean URLs and lets you pass parameters in, but will only work with elements or requests you create using JavaScript.