I know you can do it file by file.
Is there any way to do this in one step for all files in a project?
Productivity Power tools is what you need. https://visualstudiogallery.msdn.microsoft.com/dbcb8670-889e-4a54-a226-a48a15e4cace
Once you have that installed, you can find the “Remove and Sort Usings on Save” from the “Tools –> Options –> Productivity Power Tools –> PowerCommands –> Generals”. After you check that option, restart VS. Now save and you see the magic.
For VS 2015, take a look at this