Sets behave different than dicts, you need to use set operations like issubset():
>>> k
{'ip': '123.123.123.123', 'pw': 'test1234', 'port': 1234, 'debug': True}
>>> set('ip,port,pw'.split(',')).issubset(set(k.keys()))
True
>>> set('ip,port,pw'.split(',')) in set(k.keys())
False