I have just installed Anaconda 5.3 64-bit (Anaconda3-5.3.0-Windows-x86_64) on Windows 10 and am getting this error when trying to run Spyder.
pythonw.exe
I had the same problem and after trying many solutions, including the above, I finally managed to solve it.
First, open command prompt(Administrator) and input:
set CONDA_DLL_SEARCH_MODIFICATION_ENABLE=1
Then, launch the Spyder IDE, always using the command prompt by simply inputting:
spyder
It is important to always launch spyder with the command prompt. If you launch Spyder with the Anaconda Navigator, it will still give you the error message.