My machine has 8 GB or RAM, Core 2 Duo 3,06 GHZ and it seems it is not enough for Xcode 4 (4.0.1). From some time now it started to behave more and more slow. Auto completio
The following helped me A LOT - purge the workspace file.
Xcode 4 - slow performance
I didn't download the applet they're talking about but just manually doing it is working very effectively so far...
[Update: corrected the link]