My machine has 8 GB or RAM, Core 2 Duo 3,06 GHZ and it seems it is not enough for Xcode 4 (4.0.1). From some time now it started to behave more and more slow. Auto completio
I was running into performance problems with Xcode 4 and I tracked it down to the File->Source Control->Show Remote Status feature being on. Turning that feature off did the trick for me.
However, if that is not the issue then you should take samples of Xcode while it is having the performance issues. Either use the command line or the Activity Monitor application. This might give you a clue as to what the issue is. If it doesn't then post the sample here. Also, submit a bug to Apple with the sample.