ECMAScript 5 is in its final draft as I write this; It is due to include a strict mode which will prevent you from assigning to the global object, using eval, and other rest
Now that it's actually released, Firefox 4 is the winner of "first browser to support ES5 Strict Mode." Now you can start using it, as long as you test in Firefox 4.
Safari 5.1+ and Chrome 13+ Also support strict mode.
The first One is in: Besen. Implemented in Delphi. I think it's stand-alone, but I'm not sure. But it does support strict mode.
Found via this compatibility table.
Jurassic claims to support ES5 Strict Mode.