The version of clr.dll does not match the one mscordacwks.dll was built for

Question

I have a C# console app in Visual Studio 2010 that I can run just fine. When I attempt to run the process in debug mode, I am presented with the following error:

Answer 1

From what I can tell when I'm able to reproduce this error, it is caused by being in the middle of installing Windows updates. So, running updates, then postponing a reboot, then attempting to debug code is what was putting me in this broken state.