Why would an aspx file return 404 (“The page cannot be found”)

Question

Why when I access an aspx (e.g., http://www.example.com/foo.aspx - not the real site) through IE6 would I get a 404 Error (i.e., \"The page cannot be found\") in IIS6

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Answer 1

I got this issue when I tried using a different drive to host my apps. I ended up moving them to the wwwroot folder because it was working there and I did not have to time figure out why it is not working on the E:\ drive.