I have started a WinForms project a few weeks ago and as I did not really know what features I wanted, I just added them along the way. This now caused a horrible mess where
Okay,
I found some nice answers above but as per my 4+ years of experience in winform, I can say that you can use dotnet remoting for this purpose. In simple words, you need to create one solution for your business logic and client side works and another solution for connection with the database which you can called as a server. Both solution should contain some common projects and then you can easily works on your application without worry about your database.
I would suggest you to read about dotnet remoting.
Hope, this answer is helpful.