I have a problem about Genymotion after updating my OS to Windows 10, fistly it did not open with this error: Virtualization engine not found. Plugin loading aborted. Also u
In my case (Windows 10 with VirtualBox 5.0.10 and Genymotion 2.6.0) i had to:
Go to network connections (run control netconnections from cmd)
Right click and properties on VirtualBox Host-Only Network
Also some times it helps to delete the virtual device and to download it again.