The Python library pandas can read Excel spreadsheets and convert them to a pandas.DataFrame with pandas.read_excel(file) command. Under the hood,
Some responses have pointed out that odfpy or other external packages are needed to get this functionality, but note that in recent versions of Pandas (current is 1.1, August-2020) there is support for ODS format in functions like pd.ExcelWriter() and pd.read_excel(). You only need to specify the propper engine "odf" to be able of working with OpenDocument file formats (.odf, .ods, .odt).