I made a couple of changes to my working application and started getting the following error at this line of code.
Dim Deserializer As New Serialization.XmlS
It appears that you cannot locate the assembly FUSE.XmlSerializers. Check the results of the Assembly Binding Log Viewer (Fuslogvw.exe) to see where it is looking (although the list presented above seems pretty full).
Try to locate where this assembly is stored on your computer and run NGen on it to see if it is failing to load for some reason. Make sure this DLL file is appearing in your Bin\Debug directory. Visual Studio doesn't seem to get the dependencies of dependencies, and so you have to make sure you have all the files you need yourself sometimes.