Which will scale best for performance, file-size, (and my sanity): Animated .gifs or a spritesheet with animations using CSS (and JS when need be)?
I'd take a look at this:
http://adamducker.com/blog/7/animated-gif-for-css-sprites/
I personally think you'd be crazy to use a spritesheet, but i guess it depends on how many animated gifs you'd have to bring over otherwise
I don't know what your limitations are, but here's a fiddle using CSS3 step() to animate a spritesheet:
http://jsfiddle.net/simurai/CGmCe/