I want to write an HttpHandler that compiles CoffeeScript code on-the-fly and sends the resulting JavaScript code. I have tried MS [JScript][1] and IronJS without success. I
You specifically said that you wanted to write a runtime compiler, so this may not be exactly what you are looking for, but if the main point is to have a way to generate the javascript result, the Mindscape Web Workbench is interesting. It is a free extension for Visual Studio.NET 2010 and available in the Extension Manager. It gives Intellisense, syntax highlighting and compiles to JS as you write. I am just getting started using it but looks promising. Scott Hanselman talks about it here. It also supports LESS and Sass.