In looking at Go and Erlang\'s approach to concurrency, I noticed that they both rely on message passing.
This approach obviously alleviates the need for complex loc
One solution that has not been presented here is master-slave replication. If you have a large data-structure, you can replicate changes to it out to all slaves that perform the update on their copy.
This is especially interesting if one wants to scale to several machines that don't even have the possibility to share memory without very artificial setups (mmap of a block device that read/write from a remote computer's memory?)
A variant of it is to have a transaction manager that one ask nicely to update the replicated data structure, and it will make sure that it serves one and only update-request concurrently. This is more of the mnesia model for master-master replication of mnesia table-data, which qualify as "large data structure".