Whenever I consider algorithms/data structures I tend to replace the log(N) parts by constants. Oh, I know log(N) diverges - but does it matter in real world applications?>
You asked for a real-world example. I'll give you one. Computational biology. One strand of DNA encoded in ASCII is somewhere on the level of gigabytes in space. A typical database will obviously have many thousands of such strands.
Now, in the case of an indexing/searching algorithm, that log(n) multiple makes a large difference when coupled with constants. The reason why? This is one of the applications where the size of your input is astronomical. Additionally, the input size will always continue to grow.
Admittedly, these type of problems are rare. There are only so many applications this large. In those circumstances, though... it makes a world of difference.