I realize this question was asked elsewhere, but the answers seem to direct towards the paring process between Hololens and a PC, which is part of my problem.
I made
If after the update to windows 10 the problem still happens, here is a simple way to solve it.
First I was running applications in the Hololens already when suddenly I got the error message described in the original question.
So, I went to the Project Properties. The Debug Tab. There there is the "Remote Machine" space. My Hololens was selected there. But I pressed the [Find] Button and in the window that appeared I selected my hololens (it was on). Alternatively you could put the Hololens IP address there. Put Ok and voila! it works as before