Make sure you are including the web page file name in the post URL (http://yoursite/app/Page.aspx instead of http://yoursite/app)
You may need to explicitly allow POSTs to the file type of your web page. See here for instructions of how to do it in IIS. (Those instructions are for IIS 6. For IIS 7 simply go to Handler Mappings, click Edit for the appropriate entry, click the Request Restrictions button, then go to the Verbs tab.)