I have a website which I support as far as IE8, no further.
When I first launched the site, I decided to use CSS vendor prefixes for CSSs elements such as border-rad
Our approach is to drop those which aren't needed.
border-radius box-shadow
box-sizing (soon? firefox still uses it. Noted by @James Donnelly)
opacity (not a prefix, but no need for the ms-filter thingie) inline-block (same here, no need for inline+zoom fix)