This one is driving me crazy. Here\'s the XAML:
Of course the binding has to be TwoWay. But setting a ItemsSource to a control doesn't means that the DataContext (where SelectedItem variable should point to) is set. Ensure that combo's DataContext is well set. (in my case, to Page. As selectedStuff is a Page property.
cmbStuff.DataContext = Me '(from Page.Load)