I have a full aplication working with Typescript and RequireJs, it is working perfectly. I have now download WebEssentials and it is generating the minified script files. We
You can use path config to override module paths. You can even fall back to non minified files:
requirejs.config({ enforceDefine: true, paths: { jquery: [ 'lib/jquery.min', 'lib/jquery' ] } });
There may be a more general way to use min files that I don't know about!