I have a table which is as follows:
emp_name emp_address sex matial_status
uuuu eee m s
iiii iii f s
uuuu eee
I would create a new table with a unique index over the columns that you want to keep unique. Then do an insert from the old table into the new, ignoring the warnings about duplicated rows. Lastly, I would drop (or rename) the old table and replace it with the new table. In MySQL, this would look like
CREATE TABLE tmp LIKE mytable;
ALTER TABLE tmp ADD UNIQUE INDEX myindex (emp_name, emp_address, sex, marital_status);
INSERT IGNORE INTO tmp SELECT * FROM mytable;
DROP TABLE mytable;
RENAME TABLE tmp TO mytable;
Or something similar (this is totally untested).