This is a new iPhone project, only 1 target (different from this question)
On build we get:
Failed to launch simulated application: Unknown error. >
This happened to me once and I think I saw in a blog to simply quit and restart Xcode. Miraculously, it worked for me. I doubt this is the end all solutions to all problems like these though, but if you haven't yet closed Xcode, it's worth a try.