I have a controller in MVC serving up images from a database.
EDIT: This still happens if I serve up a file over completely standard means in MVC.
Eve
Looks like a known, longstanding issue with Chrome: http://crbug.com/39402
If you want it fixed sooner, star the issue. More people starring the issue will likely increase its priority and possibly get it fixed faster.
****UPDATE 1***: As of May 15 of this year (2013)--four years after this question was asked--it looks like the issue has been fixed in version 29: http://crbug.com/39402#c47
Feel free to undo all your hacks and workarounds. :]
****UPDATE 2 (2015-01)***: This is apparently still an issue for some users, according to the same issue link. :/