I have a closed non-self-intersecting polygon. Its vertices are saved in two vectors X, and Y. Finally the values of X and Y are bound between 0 and 22.
I\'d like t
One suggestion is to use the polybool function (not available in 2008b or earlier). It finds the intersection of two polygons and returns resulting vertices (or an empty vector if no vertices exist). To use it here, we iterate (using arrayfun) over all of the squares in your grid check to see whether the output argument to polybool is empty (e.g. no overlap).
N=22;
sqX = repmat([1:N]',1,N);
sqX = sqX(:);
sqY = repmat(1:N,N,1);
sqY = sqY(:);
intersects = arrayfun((@(xs,ys) ...
(~isempty(polybool('intersection',X,Y,[xs-1 xs-1 xs xs],[ys-1 ys ys ys-1])))),...
sqX,sqY);
intersects = reshape(intersects,22,22);
Here is the resulting image:

Code for plotting:
imagesc(.5:1:N-.5,.5:1:N-.5,intersects');
hold on;
plot(X,Y,'w');
for x = 1:N
plot([0 N],[x x],'-k');
plot([x x],[0 N],'-k');
end
hold off;