Seconding comments made by others: Catalyst (which more or less forked from Maypole) is by far and away the most complete and robust of them. There is a book by Jonathan Rockway that will certainly help you come to grips with it.
In addition to the 'Chained' dispatch type, the :Regex (and :LocalRegex) dispatch methods provide enormous flexibility. The latest app we've built here supports a lot of disparate-looking URLs through just a handful of subs using :LocalRegex.
I also particularly like the fact that you are not limited to a particular templating language or database. The mailing list (and the book) both have a preference for Template::Toolkit (as do I), and DBIx::Class (we continue to use Class::DBI), but you can use pretty much anything you like. Catalyst is marvelously agnostic that way.
Don't be put off by the fact Catalyst seems to require half of CPAN as dependencies. Once you get it up and running, it is a well-oiled machine. It has reached a level of maturity now that once you come to grips with it, you find it 'fades into the background'. You spend your time solving business needs, not fighting with the tools you use.
It does what it says on the tin. Catalyst++
