I have a Clickonce app from Visual Studio 2015 SP3 that is published to the network server and used in-house only. The program works just fine when launched from Visual Stud
After running in the same problem, I just found that my application was going to halt after a stupid uncaught exception.
Despite the fact that the image below is in Portuguese, Event Viewer shows the right error cause.
In my case, was a corrupted settings file!